For a long time, sleep research has treated the cerebral cortex as a passive follower reacting to signals from the deep brain. “Usually, sleep is associated with being controlled by subcortical regions,” said Geoffrey Terral, a neuroscientist at the Albert Einstein College of Medicine in New York.
The cortex is where the slow rhythms of deep sleep can be seen, but researchers assumed the signals that triggered them originated elsewhere. In a recent Nature study, Terral and Renata Batista-Brito, who runs the lab, report a population of cortical cells that challenges that assumption.
These cortical cells make up only around one percent of the cortex’s inhibitory neurons, and switching them on in a mouse puts the animal to sleep. “What our work shows is that the cortex can not only see this rhythm but also initiate it by itself, and this is sufficient to promote sleep,” Terral said.
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